Evaluate clients obtaining acetaminophen and codeine phosphate tablets and any CYP2D6 inhibitor for indicators and symptoms which could reflect opioid toxicity and opioid withdrawal when acetaminophen and codeine phosphate tablets are made use of together with inhibitors of CYP2D6.
You shouldn't use codeine For those who have serious respiration difficulties, a blockage inside your abdomen or intestines, or frequent bronchial asthma attacks or hyperventilation.
Educate patients and caregivers on how to acknowledge respiratory depression and emphasize the significance of calling 911 or acquiring unexpected emergency health care support without delay while in the function of the acknowledged or suspected overdose (see PRECAUTIONS, Details for Patients/Caregivers).
Overestimating the acetaminophen and codeine phosphate tablets dosage when converting sufferers from Yet another opioid solution may end up in a lethal overdose with the first dose.
Hepatotoxicity Acetaminophen continues to be related to instances of acute liver failure, occasionally leading to liver transplant and Loss of life.
Recommend caregivers that acetaminophen and codeine phosphate tablets are contraindicated in all little ones youthful than twelve several years of age and in kids younger than 18 years of age following tonsillectomy and/or adenoidectomy.
Have been explained to by your Health care supplier that you will be a “speedy metabolizer” of particular medicines.
Situations of OIH have been documented, both equally with small-term and more time-term usage of opioid analgesics. Although the system of OIH just isn't absolutely understood, a number of biochemical pathways are already implicated. Medical literature suggests a solid biologic plausibility between opioid analgesics and OIH and allodynia.
It's not a complete list of doable Uncomfortable side effects. If you discover other consequences not listed over, Speak to your medical doctor or pharmacist.
If concomitant usage check here of CYP3A4 inhibitor is necessary, contemplate dosage reduction of acetaminophen and codeine tablets right until stable drug outcomes are realized. Evaluate clients at Recurrent intervals for respiratory depression and sedation.
While it can help Many individuals, this medication may possibly sometimes read more cause dependancy. This possibility could be greater When you have a substance use ailment (for instance check here overuse of or addiction to prescription drugs/Alcoholic beverages).
Expecting click here or planning to become pregnant. Use of acetaminophen read more and codeine phosphate tablets for an extended timeframe in the course of pregnancy could potentially cause withdrawal signs in the new child infant that might be everyday living-threatening if not regarded and handled.
Like other narcotic medicines, codeine can slow your respiratory. Demise may possibly take place if breathing results in being way too weak.
Because of the risk of respiratory despair with concomitant utilization of skeletal muscle mass relaxants and opioids, look at prescribing naloxone for that unexpected emergency treatment method of opioid overdose (see WARNINGS).